Genetic Imprinting: Conflict at the Callipyge Locus
نویسندگان
چکیده
The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mechanism.
منابع مشابه
Polar Overdominance at the Ovine Callipyge Locus Supports Trans Interaction between the Products of Reciprocally Imprinted Genes
SYMMARY The callipyge phenotype in sheep is an inherited muscular hypertrophy affecting only heterozygous individuals receiving the CLPG mutation from their father. The CLPG mutation has been identified as a single nucleotide substitution in what is likely a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of cal...
متن کاملDetection of a quantitative trait locus for ham weight with polar overdominance near the ortholog of the callipyge locus in an experimental pig F2 population.
The distal part of SSC7, which contains the ortholog to the ovine region encompassing the callipyge locus, was analyzed in a Piétrain F(2) resource population comprising more than 2,700 offspring. The aim of the study was to map QTL affecting carcass traits comparable with the callipyge phenotype in sheep. We applied an interval mapping approach using 14 microsatellite markers and detected 3 QT...
متن کاملToward molecular understanding of polar overdominance at the ovine callipyge locus.
callipyge phenotype (Gk calli-beautiful +-pyge buttocks) is a generalized muscular hypertrophy described in sheep. It is due to an increase in the size and proportion of fast twitch muscle fibers. It manifests itself only after birth at ~1 month of age. It exhibits a rostro-caudal gradient being more pronounced in the muscle of the pelvic limb and torso, hence its name. It is accompanied by a d...
متن کاملThe callipyge locus: evidence for the trans interaction of reciprocally imprinted genes.
The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father. The CLPG mutation is a single nucleotide substitution in what is probably a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of callipyge, referred to a...
متن کاملThe effect of genetic conflict on genomic imprinting and modification of expression at a sex-linked locus.
We examine how genomic imprinting may have evolved at an X-linked locus, using six diallelic models of selection in which one allele is imprintable and the other is not. Selection pressures are generated by genetic conflict between mothers and their offspring. The various models describe cases of maternal and paternal inactivation, in which females may be monogamous or bigamous. When inactivati...
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ورودعنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005